Organocatalytic Enantioselective Vinylogous Henry Reaction of 3,5-Dimethyl-4-nitroisoxazole with Trifluoromethyl Ketones
نویسندگان
چکیده
منابع مشابه
Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones.
Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%).
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ژورنال
عنوان ژورنال: Synthesis
سال: 2017
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-0036-1590928